Either
1) Sweet Home reboot - basically Resident Evil with Paranormal elements. Brilliant if it was done with modern day interpretations of ghost hunters maybe done in night vision art style. Of course the four character who could all die and RPG elements would be cool too
2) Clock Tower reboot: Clock tower is still scary, and if it was refreshed as a 2.5D point and click Survival Horror / side scrolling game with next gen spooky visuals and 5.1 surround sound, it'd be terrifying. Give it a real Edgar Allen Poe / J-Horror feel
3) Project Zero / Fatal Frame reboot - I loved the series when it came out in Europe, and having the gamepad as the camera would just be amazingly awesome! You could almost have the TV as third person and the gamepad as first person! Of course it'd really have to have a Nintendo reboot IMO start again, start afresh. Again give a real J-Horror feel to the game.
Boy I miss these games, especially playing the translated/hacked Sweet Home ROM - almost makes me wish Capcom went ahead with the Sweet Home remake instead of Resident Evil.