Well, it wasn't that big of an advantage for Acclaim, as they quickly went out of business.
Shifting focus to the PS2 is what sunk them. The Turok games sold very well on the N64, but tanked when it went multi platform. They also lost the NFL Quarterback crowd when the N64 retired. Their sports games werent successful on other platfoms, and with the Gamecube Madden was a better game right out of the gate, so a lot NFL Quarterback gamers on the N64 went to Madden with the Gamecube. Acclaim made a lot of money with the N64, they lost it very quickly the following generation. This is definately an opportunity for other publishers and developers.