They can't go there showing Yoshi's Epic Yarn or Kirby Triple Deluxe, it would have to be something that goes with that audience (the people tuning in for Uncharted and Metal Gear). They would have to show something like Zelda, Super Smash Bros, or Monolith Soft's X, Zelda would be the big one.
Aonuma wanted to show Zelda at E3, didn't get to show, wanted to show it at Comic Con, again didn't get to show it. I believe this will be the time.
We will probably get something similar to this then the full gameplay reveal at E3.