As far as being the protag of a mainline Zelda game? No. Link has always been a male. No matter what people say, Link is a character, and he's male. There's a reason he always looks similar (green tunic, yellow droopy hair), and he's always called Link in non-Zelda games. MK8, Smash... Always referred to as Link. Changing that for no reason other than to appease SJWs is not a good idea. If they come up with a good story (or even better, gameplay) reason to have a female Link, then by all means, do it.
Linkle being the protagonist of a mainline Zelda =/= Linkle being Link.
Either way, Link as a character is not defined by his gender, so I don't know what your problem is here. It's not the same situation as in, say, Mario suddenly turning into a woman, because Mario in every game is the same entity while most Zelda games have a different Link.